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From stocktwits forum: $ICPT a Stanford University abstract notes that liver transplant waitlist mortality among patients with PBC and decompensated cirrhosis is lower since Ocaliva approval compared to before Ocaliva approval.
Just a note re NonAlcoholic SteatoHepatitis (if I type the Acronym the post won't go through for whatever reason). The FDA rejected $ICPT obeticholic acid (per @naturebiotech on t w i t t e r). The poster called it "another disappointment for a crowded field lettered with failures" - very poetic and more importantly shows what a great opportunity $ARWR to let the world know how it can solve problems not yet tackled by the many who have attempted and failed.
From stocktwits forum: 12/24/21, 06:39 AM $ICPT , $ 80 to $ 100 with positive Phase 3 results or $ 12 to $ 15 with failed trial. Unbelievably favorable Risk-Reward ratio. With 40 % short ratio. Load up guys.
From Dough; GS await $SRPT key 1Q19 event - MYO-101 Ph1/2 limb girdle muscular dystrophy biopsy data which expect to be positive based on gene expression levels of ~20%+ above baseline (measured by IHC) $ICPT NASH data is also expected imminently (1Q) – highlight favorably risk/reward HERE.
Sold other than 300 stock. They are profit only and will hold forever. Lately I am exiting most of my biotech.
I still hold them in my IRA but no more regular account. Here is list of biotech I give up hope. 1.> $AMRN 2.> $BLUE 3.> $MDGL 4.> $ICPT 5.> $PBYI 6.> $CLVS (Only sold half before their disaster offering tank stock. HOlding to see if we get combo trial result boost. But may exit as well.) 7.> NKTR (Half) 8.> AERI ( Half)
I am holding very large GILD (3000) and MRNA (3000). Sure I am shorting some high flyer so part of reason to sell is get buying power to I can hold or short more on those. Some day they will print solid profit but right now anything I touch on short, it start flying high and only stop if give up.
Most Shorted Stocks According To S3 $CRTX – SI 58% $PPSI – SI 47% $GREE – SI 45% $IFMK – SI 45% $BYND – SI 39% $IMUN – SI 38% $BLNK – SI 37% $ICPT – SI 35% $BYSI – SI 33% $ESPR – SI 33% $BEEM – SI 33% $LMND – SI 33%
Stocks with the highest short interest $BFRI – SI 83% $CRTX – SI 55% $IMUN – SI 41% $LGVN – SI 38% $ICPT – SI 35% $SAVA – SI 35% $PRLD – SI 35% $BLNK – SI 35% $LMND – SI 35% $WEBR – SI 34% $RELI – SI 34%
Wells Fargo lowering $ICPT PT to 113 the expert described the benefit of OCA in NASH as #underwhelming, well below that seen in the earlier FLINT study, and not sufficient to change practice, particularly given high pruritus rates.
JMP's Liisa Bayko (ranked 503 on 5.800 analysts) comments on $ICPT and PDUFA news; continues to recommend Intercept shares and maintains Outperform rating and **$200** price target
Wells Fargo lowering $ICPT PT to 113 the expert described the benefit of OCA in NASH as #underwhelming, well below that seen in the earlier FLINT study, and not sufficient to change practice, particularly given high pruritus rates.
"The phase 2 study has the surrogate and primary endpoint as HVPG - Hepatic venous pressure gradient. so if in Q4 2018 the phase 2 endpoint HVPG is met, then accelerated approval is possible without the need to run a phase 3 for approval."
"the phase 2a pilot study for portal hypertension Conatus achieved a 92% response rate 11 out of 12 patients responding after only 4 weeks of treatment with emricasan given 25 mg twice daily."
CNAT the next to report NASH Cirrhosis PH Phase 2b/3 at 5MG, 25MG, 50MG twice daily... if GOOD likely FDA approval... Trial data in or before Q4 2018.
$ICPT met the end point but not much more in order to be a blockbuster they should showed much better results with 0 side effects $3.5B is way overpriced expect it to go down to around $2B.
Cantor 2020 #biotech outlook
Top picks:
- Large-cap: $VRTX $AMGN
- Mid-cap: $SRPT $ALNY
- Small-cap: $TGTX $ICPT $GBT $AGIO
- Favorite binary: $MYOK
$ICPT
a Stanford University abstract notes that liver transplant waitlist mortality among patients with PBC and decompensated cirrhosis is lower since Ocaliva approval compared to before Ocaliva approval.
Top takeout targets, per new Credit Suisse investor survey:
1. $CLVS
2. $SRPT
3. $ALDR
4. $INCY
5. $BMRN
6. $GLPG
7. $ALXN
8. $IMMU
9. $ICPT
10. $VKTX
Intercept's Pain Is Galectin's Gain: Clinical Outcomes In NASH Are Crucial
$GALT $ICPT $GNFT
12/24/21, 06:39 AM
$ICPT
, $ 80 to $ 100 with positive Phase 3 results or $ 12 to $ 15 with failed trial. Unbelievably favorable Risk-Reward ratio. With 40 % short ratio. Load up guys.
GS await $SRPT key 1Q19 event - MYO-101 Ph1/2 limb girdle muscular dystrophy biopsy data which expect to be positive based on gene expression levels of ~20%+ above baseline (measured by IHC) $ICPT NASH data is also expected imminently (1Q) – highlight favorably risk/reward HERE.
I still hold them in my IRA but no more regular account.
Here is list of biotech I give up hope.
1.> $AMRN
2.> $BLUE
3.> $MDGL
4.> $ICPT
5.> $PBYI
6.> $CLVS (Only sold half before their disaster offering tank stock. HOlding to see if we get combo trial result boost. But may exit as well.)
7.> NKTR (Half)
8.> AERI ( Half)
I am holding very large GILD (3000) and MRNA (3000). Sure I am shorting some high flyer so part of reason to sell is get buying power to I can hold or short more on those. Some day they will print solid profit but right now anything I touch on short, it start flying high and only stop if give up.
$CRTX – SI 58%
$PPSI – SI 47%
$GREE – SI 45%
$IFMK – SI 45%
$BYND – SI 39%
$IMUN – SI 38%
$BLNK – SI 37%
$ICPT – SI 35%
$BYSI – SI 33%
$ESPR – SI 33%
$BEEM – SI 33%
$LMND – SI 33%
$BFRI – SI 83%
$CRTX – SI 55%
$IMUN – SI 41%
$LGVN – SI 38%
$ICPT – SI 35%
$SAVA – SI 35%
$PRLD – SI 35%
$BLNK – SI 35%
$LMND – SI 35%
$WEBR – SI 34%
$RELI – SI 34%
"the phase 2a pilot study for portal hypertension Conatus achieved a 92% response rate 11 out of 12 patients responding after only 4 weeks of treatment with emricasan given 25 mg twice daily."
CNAT the next to report NASH Cirrhosis PH Phase 2b/3 at 5MG, 25MG, 50MG twice daily... if GOOD likely FDA approval... Trial data in or before Q4 2018.
NASH $GALT $VKTX $GLMD $MDLG $ICPT
https://www.youtube.com/watch?v=xxzTsexijPU&feature=youtu.be
CITI SMid Biotech Catalyst Outlook
72 pages $SRPT $FGEN $ICPT, $NVAX $SLDB $NERV $SNDX, $MDCO & more. CITI TOP 2 PICS $FGEN $SRPT 👍
Stocks with the highest short interest
$BFRI – SI 83%
$CRTX – SI 55%
$IMUN – SI 41%
$LGVN – SI 38%
$ICPT – SI 35%
$SAVA – SI 35%
$PRLD – SI 35%
$SWTX Ph 3
$ADAG Ph 2
$ICPT Ph 3
$IMMP Ph 2
$VERU Ph 2
$DMAC Ph 2
$KLDO Ph 2
$MREO Ph 2
$SLS Ph 2
$CORT Ph 2
$CRBP Ph 2
$PRAX Ph 2
$AMRN Ph 2
$ZEAL Ph 3
$CBAY Ph 2
$ARVN Ph 2
$TNXP Ph 3
$FGEN Ph 2
Catalyst Calendar => http://bpiq.com/fda-catalyst-calendar
CITI SMid Biotech Catalyst Outlook
72 pages $SRPT $FGEN $ICPT, $NVAX $SLDB $NERV $SNDX, $MDCO & more. CITI TOP 2 PICS $FGEN $SRPT